以左旋氧氟沙星为基础抗幽门螺杆菌补救治疗的疗效观察

• 作 者: 张勇 吴杰 贾业贵
• 机 构: 江汉大学附属医院武汉市第六医院,江汉大学附属医院武汉市第六医院,江汉大学附属医院武汉市第六医院 武汉430015,武汉430015,武汉430015
• 出 处: 临床消化病杂志
• 发表日期: 2007年05期
• 关键词: 左旋氧氟沙星 幽门螺旋杆菌 补救治疗

目的观察以左旋氧沙星为基础抗幽门螺杆菌补救治疗的疗效和药物副作用。方法经常规三联抗幽门螺杆菌治疗失败患者93例,随机分为A、B2组,A组49例,给予以左旋氧氟沙星为基础的三联补救治疗7d;B组44例,给予常规四联补救治疗,对照观察药物疗效及副作用。结果A组45例完成治疗及随访,其中42例补救治疗成功,4例发生轻微不良反应;B组39例完成治疗及随访,其中30例补救治疗成功,5例发生药物不良反应。结论以左旋氧氟沙星为基础的抗幽门螺杆菌治疗疗效优于常规四联补救治疗,疗程短、药物副作用少,值得临床推广。

Objective To observe the efficacy and drug side effects of levofloxacin-based anti-Helicobacter pylori remedy. Methods Ninety-three patients with routine triple anti-Helicobacter pylori infection were randomly divided into A, B2 group, A group, 49 patients received levofloxacin-based triple salvage therapy for 7 days; B group, 44 patients, Remedial treatment, control the efficacy of drugs and side effects observed. Results A group of 45 patients completed the treatment and follow-up, of which 42 cases of successful remedial treatment, 4 cases of minor adverse reactions; B group of 39 patients completed the treatment and follow-up, of which 30 cases of successful remedial treatment, 5 cases of adverse drug reactions. Conclusion Levofloxacin-based anti-Helicobacter pylori treatment is superior to conventional quadruple salvage therapy, with short course of treatment and few drug side effects, which is worthy of clinical promotion.