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目的探讨新生儿先天性甲状腺功能低下症(CH)与出生体重及胎龄关系。方法 1500例实施先天性甲状腺功能低下症筛查的新生儿,根据新生儿胎龄分为早产组(<37周,298例)、足月组(37~42周,851例)及超龄组(>42周,351例);根据出生儿出生体重分为低出生体重组(<2500 g,267例)、正常体重组(2500~4000 g,832例)及巨大儿组(>4000 g,401例)。新生儿出生后应用时间分辨荧光免疫方法 (TRFIA)测定足跟血斑的促甲状腺素(TSH)指标。对检测阳性患儿实施甲状腺功能检测。评估出生体重及胎龄与新生儿先天性甲状腺功能低下症的关系。结果超龄组新生儿先天性甲状腺功能低下症发病率为3.70%显著高于早产组的1.68%与足月组的1.53%,差异具有统计学意义(P<0.05)。正常体重组新生儿先天性甲状腺功能低下症发病率为0.60%,低于低出生体重组的3.75%与巨大儿的3.99%,差异具有统计学意义(P<0.05)。结论通过对新生儿实施先天性甲状腺功能低下症筛查,超龄与出生体重异常新生儿患先天性甲状腺功能低下症几率高,孕期有效干预避免超龄与出生体重异常对于降低新生儿先天性甲状腺功能低下症具有重要临床指导意义。
Objective To investigate the relationship between neonatal congenital hypothyroidism (CH) and birth weight and gestational age. Methods One hundred and fifty-five newborns with congenital hypothyroidism were enrolled in this study. According to the neonatal gestational age, they were divided into preterm birth group (<37 weeks, 298 cases), full term group (37 to 42 weeks, 851 cases) > 42 weeks and 351 cases). According to the birth weight of the newborn, the birth weight was divided into low birth weight group (<2500 g, 267 cases), normal weight group (2500 ~ 4000 g, 832 cases) example). After neonatal birth, time-dependent fluorescence immunosorbent assay (TRFIA) was used to measure thyrotropin (TSH) in heel blood spots. The detection of positive children with thyroid function testing. To evaluate the relationship between birth weight and gestational age and neonatal congenital hypothyroidism. Results The incidence of congenital hypothyroidism in over-age group was 3.70%, significantly higher than that in preterm group (1.68%) and full-term group (1.53%), the difference was statistically significant (P <0.05). The incidence of congenital hypothyroidism in normal weight group was 0.60%, which was lower than 3.75% in low birth weight group and 3.99% in macrosomia group, the difference was statistically significant (P <0.05). Conclusions The screening of congenital hypothyroidism in newborns may lead to over-age and abnormal birth weight. The incidence of congenital hypothyroidism in newborns is high. Effective intervention during pregnancy to prevent over-birth and birth weight abnormalities can reduce congenital hypothyroidism Disease has important clinical significance.