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目的 评价半定量99Tcm 甲氧基异丁基异腈 (MIBI)显像法对甲状腺癌的诊断价值。方法 对 2 6 9例经病理检查或细胞学证实的甲状腺结节患者的99Tcm MIBI显像结果进行分析 ,计算其 5和 6 0min摄取比值 (UR) ,并以甲状腺良性结节组UR值的 x +s为诊断阈值 ,分析假阳性和假阴性。结果 甲状腺良性结节组 5和 6 0minUR分别为 0 .80 6± 0 .192和 0 .847± 0 .189,而甲状腺癌组UR值分别为 1.839± 0 .734和 1.6 75± 0 5 5 1,同组两时相比较P >0 .0 5 ,而组间两时相比较P <0 .0 0 1。以良性结节组 x +s为诊断阈值 ,99Tcm MIBI对甲状腺癌诊断的灵敏度、特异性和准确性分别为89 2 4%、93.82 %和 87.36 % ,假阳性率和假阴性率分别为 15 .78%和 12 .0 9% ,阳性预测值和阴性预测值分别为 77.5 7%和 93.83%。结论 99Tcm MIBI半定量显像能较好地鉴别甲状腺结节的良恶性 ,但缺乏特异性 ,甲状腺腺瘤和结节性甲状腺肿易出现假阳性
Objective To evaluate the value of semi-quantitative 99Tcm methoxyisobutylisonitrile (MIBI) imaging in the diagnosis of thyroid cancer. Methods The results of 99Tcm MIBI imaging in 269 thyroid nodules confirmed by pathology or cytology were analyzed. The ratio of 5 and 60 min urinary intake (UR) was calculated. The value of UR in xenograft thyroid nodules x + s is the diagnostic threshold, false positives and false negatives are analyzed. Results The mean thyroid benign nodules at 5 and 60 minUR were 0.80 6 ± 0.192 and 0.8447 ± 0.189, respectively, while the values of UR in thyroid cancer were 1.839 ± 0.734 and 1.6 75 ± 0 5 5 1, respectively , P> 0. 05 in the same group at 2 o’clock, P <0. The sensitivity, specificity and accuracy of 99Tcm MIBI for the diagnosis of thyroid cancer were 89.24%, 93.82% and 87.36%, respectively. The false-positive rate and false-negative rate were 15%. 78% and 12. 09% respectively. The positive predictive value and negative predictive value were 77.5 7% and 93.83% respectively. Conclusion 99Tcm MIBI semi-quantitative imaging can better identify the benign and malignant thyroid nodules, but the lack of specificity, thyroid adenoma and nodular goiter prone to false positive