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近年来,随着放射治疗学的进展,大剂量全身或上半身照射已用于某些恶性肿瘤的临床治疗。进行骨髓等造血细胞侈植的急性白血病、再生障碍性贫血等病人,大剂量照射是经常采用的免疫抑制预处理方法。许多临床观察表明,大剂量全身或上半身照射后常发生严重的放射性肺炎。由于其发生率高,往往造成病人死亡,是影响疗效的重要因素,因此成为临床上十分关注的和迫切需要解决的问题。下面就放射性肺炎的发病因素、临床表现、病理改变及防治等问题的近况作一简介。
In recent years, with the progress of radiotherapy, high-dose whole body or upper body irradiation has been used in the clinical treatment of certain malignant tumors. Hematopoietic cells such as bone marrow transplantation of acute leukemia, aplastic anemia and other patients, high-dose irradiation is often used immunosuppressive pretreatment. Many clinical observations have shown that severe radiation pneumonitis often occurs after high-dose whole body or upper body irradiation. Because of its high incidence, it often results in the death of patients and is an important factor affecting the curative effect. Therefore, it has become a clinically very important and urgent problem to be solved. The following on the incidence of radiation pneumonitis, clinical manifestations, pathological changes and prevention and treatment of the status quo for a brief introduction.