论文部分内容阅读
病毒唑(Virasole)即三唑核苷(1-β-D-Ribofuranosyl-1,2,4-triasole-3-carboximidc),自Sidwell等(1972)报道了本品抗病毒作用的实验资料后,由于其抗病毒谱广,活性较强,毒副作用较少而为国内外学者重视。本品体外试验有对抗多种RNA和DNA病毒的活性,其作用机理在于阻碍病毒核酸的合成。洗涤剂多系阴离子表面活性剂,有损伤细菌细胞膜结构的活性,作用迅速。以上二者单独使用时无直接灭活乙型肝炎表面抗原(HBsAg)的作用。为探索二者之间有无协同作用,我们做了病毒唑洗涤剂溶液对HBsAg的抑制试验,现报道如下。实验材料
Virasole, 1-β-D-Ribofuranosyl-1,2,4-triasole-3-carboximidc, has been reported by Sidwell et al. (1972) for the antiviral effect of this product. Due to its wide spectrum of anti-virus, strong activity, fewer side effects and domestic and foreign scholars attention. This product in vitro test against a variety of RNA and DNA virus activity, its mechanism of action hinders the synthesis of viral nucleic acid. Multi-line detergent anionic surfactant, bacterial cell membrane damage the activity of the structure, the role of rapid. When used alone, there is no direct inactivation of hepatitis B surface antigen (HBsAg). In order to explore the synergy between the two, we have done a test of inhibition of HBsAg with ribavirin detergent solution, are reported below. Experimental Materials