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常见同时感染几种寄生虫。许多化疗药物有抑制免疫功能的作用,在杀灭某种寄生虫的同时,可影响另一种伴发的寄生虫生长,作者据此应用单独或合并感染墨西哥利什曼原虫和约氏疟原虫的BALB/c小鼠为模型,用葡萄糖酸锑钠(五价锑)或T-抑制细胞抑制剂甲氰咪胍治疗,以评价其对两种寄生虫(单独和并存)生长的影响。用八周龄小鼠经右后足垫皮下感染墨西哥利什曼原虫亚马孙亚种Walter Reed株227无鞭毛体1×10~6个。每周用游标卡尺测量双后足垫直径(mm),以感染足数值减去未感染足数值,确定病灶大小,以此来判断
Common at the same time infected with several parasites. Many chemotherapeutic agents have an immunosuppressive effect that, while killing certain parasites, can affect another parasitic growth associated with the use of the chemotherapeutic agent alone or in combination with Leishmania mairei and Plasmodium yoelii BALB / c mice were modeled with antimony sodium gluconate (pentavalent antimony) or the T-suppressor cytostatin cimetidine to evaluate its effect on the growth of both parasites (alone and in coexistence). Eight-week-old mice were subcutaneously infected with 1 x 10-6 amastigotes of the Walter Reed strain 227 of Leishmania mexicana via the right hind footpad. The diameter of the double hind footpad (mm) is measured weekly with a vernier caliper to determine the lesion size by infecting the foot number minus the uninfected foot value