论文部分内容阅读
本文研究了片剂顶裂的原因。过去认为,片剂的顶裂是由于材料的变形性(塑性或弹性)或是由于包裹在片剂孔隙中的空气的膨胀。本文作者采用微粉化的安替比林(A)、微晶纤维素(AV)加硬脂酸镁(1％)的混合物,以及由A颗粒(39％)、乳糖(60％)加硬脂酸镁(1％)组成的混合物作为压片材料[A颗粒由微粒化A与8％的醇/水(3+1)制备]。同时使用不同型号压片机及张力试验器、频率转换器等精密仪器,研究了包括空气压力、压片压力、解压速度等多种因素对顶裂的影响,测定结果如下。空气压力无论是在空气或真空以及氦气中压制的
This article studies the causes of tablet cracking. It has been previously thought that the crazing of tablets is due to the material’s deformability (plasticity or elasticity) or to the expansion of air entrapped in the pores of the tablet. The authors used a mixture of micronized antipyrine (A), microcrystalline cellulose (AV) plus magnesium stearate (1%), and a mixture of A granules (39%), lactose Magnesium acetate (1%) was used as the tabletting material [A particle was prepared from micronized A with 8% alcohol / water (3 + 1)]. At the same time using different types of tablet press and tension tester, frequency converter and other precision instruments, including air pressure, tabletting pressure, decompression speed and other factors on the impact of cracking, measured results are as follows. Air pressure is suppressed either in air or in vacuum as well as in helium