Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic b

• 作 者: NicholasGTheodorakis YiningNWa
• 机 构: DivisionofTransplantSurgeryDepartmentofSurgerySchoolofMedicineIndianaUniversity,SchoolofMedicineUniv
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2015年14期
• 关键词: PORTAL hypertension THALIDOMIDE NITRIC oxide KNOCK Portal hypertensionThalidomid
• 基金项目: Supported by The Departments of Surgery at the University of Rochester and Indiana University

AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and morbidity.Previous reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this acti