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消化性食管炎是众所周知的酒精中毒并发症.能增高食管炎发病率的因素有:下食管括约肌(LES)压力的变化,食管运动异常引起的远端食管排酸(酸清除率)障碍或唾液流量及组成的改变,这些因素可助长胃内容物尤其是胃酸与食管粘膜的长期接触.大多数对LES功能及食管运动的研究,一直集中于饮酒的急性作用.作者用较新的技术,研究在无严重肝损害时,长期过度饮酒者食管运动及排酸能力、唾液流量、组成及酸中和力是否存在任何异常,以及停止过度饮酒是否能逆转这些变化.方法:1.运动研究:8名平均年龄54岁,长期大
Digestive esophagitis is a well-known complication of alcoholism, and factors that increase the incidence of esophagitis include changes in the pressure in the lower esophageal sphincter (LES), dyspnea in the distal esophagus (acid clearance) caused by esophageal motility disorders, or saliva Flow and composition changes that contribute to the long-term exposure of gastric contents, especially gastric acid, to esophageal mucosa.Most studies of LES function and esophageal motility have focused on the acute effects of alcohol consumption.With newer techniques, In the absence of severe hepatic impairment, esophageal motility and esophageal motility, saliva flow, composition and acid-neutralizing force in the long-term over-drinkers were tested for any abnormalities and whether over-drinking was able to reverse these changes.Methods1. The average age of 54 years old, long-term large