论文部分内容阅读
我们用环孢霉素 A 治疗3例 Graves 病浸润性突眼,收到良好效果,现报道如下。例1 患者,女性,22岁。1986年6月出现食欲亢进,多汗,颈部增粗及突眼,当时查 T_3、T_4 及甲状腺吸~(131)碘率均升高,确诊 Graves 病。给予他巴唑及强的松治疗,甲亢控制,但突眼无改善,并出现怕光流泪加重,1988年3月5日入院。体检:双侧突眼Ⅳ级、双侧突眼度为27mm,甲状腺Ⅱ度肿大,血管杂音明显,T_3 4.2nmol/L(正常值52～195nmol/L),TGA1∶40(+),IgG17.2g/L,诊断 Graves 病浸润性突眼。给予他巴唑5mg,每日三次,甲状腺片20mg,每日三次,环孢霉素 A 每日5mg/kg,分3次口服,治疗10天后,结膜充血水肿、怕光流泪明显改善,突眼度减少为26mm,33天后减少至25mm,停
We use Cyclosporin A treatment of 3 Graves disease infiltrating exophthalmos, received good results, are reported below. Example 1 Patient, female, 22 years old. In June 1986 appetite hyperkeratosis, hyperhidrosis, neck thickening and exophthalmos, then check T_3, T_4 and thyroid suction ~ (131) iodine rates were elevated, diagnosis of Graves disease. Given methimazole and prednisone treatment, hyperthyroidism control, but no improvement in exophthalmos, and the fear of light and tear increased, March 5, 1988 admitted to hospital. Physical examination: Bilateral exophthalmos grade Ⅳ, bilateral exophthalmos 27mm, thyroid Ⅱ degree swollen, vascular murmur, T_3 4.2nmol / L (normal 52 ~ 195nmol / L), TGA1:40 (+), IgG17 .2 g / L, diagnosis of Graves disease infiltrative exophthalmos. Given methimazole 5mg, three times a day, thyroid tablets 20mg, three times a day, cyclosporine A daily 5mg / kg, 3 times orally, after 10 days of treatment, conjunctival congestion and edema, photophobia was significantly improved, exophthalmos Degrees reduced to 26mm, reduced to 25mm after 33 days, stopped