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目的研究子痫前期患者子宫蜕膜组织中树突状细胞的形态、分布及数量,探讨其在子痫前期发病机制中的作用。方法采集各40例正常妊娠孕妇、子痫前期轻度及重度患者子宫蜕膜组织,采用免疫组化法分别检测CD83+、CD1a+树突状细胞的形态、数量及分布。结果 (1)CD83+树突状细胞在子痫前期(重度)组比子痫前期(轻度)组增多,正常组表达最少,各组比较差异均有统计学意义(P<0.01)。(2)CD1a+树突状细胞在正常组表达最高,子痫前期(重度)组比子痫前期(轻度)组降低,各组比较差异均有统计学意义(P<0.01)。结论树突状细胞可能在子痫前期的发病机制中起到一定的作用。
Objective To study the morphology, distribution and quantity of dendritic cells in the decidual tissue of patients with preeclampsia and to explore its role in the pathogenesis of preeclampsia. Methods 40 cases of normal pregnant women, mild and severe preeclampsia uterine decidua were collected. The morphology, number and distribution of CD83 + and CD1a + dendritic cells were detected by immunohistochemistry. Results (1) CD83 + dendritic cells increased in preeclampsia (severe) group compared with preeclampsia (mild) group, and the expression of CD83 + dendritic cells was the least in normal group (P <0.01). (2) The expression of CD1a + dendritic cells in normal group was the highest, while that in preeclampsia (severe) group was lower than in preeclampsia (mild) group. There was significant difference between each group (P <0.01). Conclusion Dendritic cells may play a role in the pathogenesis of preeclampsia.