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氢化可的松注射液用于静脉滴注,系用乙醇作溶剂,含醇量为47～55%。含醇量过高会刺激血管内壁,含醇量低,则注射液中可的松易析出。《中国药典》1985年版采用气相色谱法测定含醇量。乙醇的浓度和相对密度密切相关,通过相对密度的测定(比重瓶法),查表可知含醇量。氢化可的松注射液中氢化可的松的含量很少,每毫升仅5mg,此溶质对乙醇的相对密度影响甚微,这样通过直接测定注射液的相对密度,查表可得近似的含醇量。我们对市售的六批样品用药典法和比重瓶法直接测定注射液
Hydrocortisone injection for intravenous infusion, the Department of ethanol as a solvent, alcohol content of 47 to 55%. Alcohol content will stimulate the vascular wall is too high, with low alcohol content, the injection of cortisone is easy to precipitate. “Chinese Pharmacopoeia” 1985 edition Determination of alcohol content by gas chromatography. Ethanol concentration and relative density are closely related to the determination of the relative density (pycnometer method), look-up table shows alcohol content. Hydrocortisone hydrocortisone injection content is very small, only 5mg / ml, the solute has little effect on the relative density of ethanol, so by directly measuring the relative density of the injection, look-up table can be obtained with similar alcohol the amount. We tested the commercially available six batches of samples using the Codex Alimentarius and Pycnometer methods for the direct determination of injections