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目的探讨抗环瓜氨酸肽(CCP)抗体在类风湿性关节(RA)炎诊断中的应用价值。方法用酶联免疫吸附试验(ELISA)法分别检测109例RA、42例其他风湿免疫病患者及30例健康体检者血清中的抗-CCP抗体,用速率散射比浊法检测类风湿因子(RF),并进行比较分析。结果抗CC-P抗体和RF的敏感性分别为62.4%和70.6%,差异无统计学意义(χ2=3.5,P>0.05);抗-CCP特异性为95.8%,明显高于RF的81.9%,两者之间有显著性差异(χ2=38.2,P<0.01)。两者联合检测敏感性下降(56.0%),特异性却升高(98.6%);两者总体符合率78.9%;抗CC-P与RF检测对RA的诊断差异无统计学意义(χ2=2.8,P>0.05),两者之间存在明显的相关性(r=0.547,P<0.01)。结论抗-CCP抗体是诊断RA的一个高度特异性指标,有很好的临床应用价值。
Objective To investigate the value of anti-cyclic citrullinated peptide (CCP) antibody in the diagnosis of rheumatoid arthritis (RA). Methods Serum anti-CCP antibodies of 109 patients with RA, 42 patients with other rheumatoid immune diseases and 30 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA). The levels of rheumatoid factor (RF) ), And comparative analysis. Results The sensitivity of anti-CC-P antibody and RF was 62.4% and 70.6% respectively, with no significant difference (χ2 = 3.5, P> 0.05). The anti-CCP specificity was 95.8% , There was a significant difference between the two (χ2 = 38.2, P <0.01). The sensitivity of combined detection was decreased (56.0%) and specificity (98.6%). The overall coincidence rate was 78.9%. There was no significant difference between the two groups in the diagnosis of RA (χ2 = 2.8 , P> 0.05). There was a significant correlation between them (r = 0.547, P <0.01). Conclusion anti-CCP antibody is a highly specific diagnostic indicator of RA, has a good clinical value.