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报告了以伊达比星(IDA)为主联合阿糖胞替(Am-C)、长春新碱(VCR)、强的松等药物治疗8例难治性复发性急性白血病,其中AML5例,ALL3例。除1例AML于治疗中脑出血死亡外,其余7例中,3例完全缓解(42.8%),2例部分缓解(28.7%),2例无效,总有效率71.5%。8例均有明显血像抑制,4例骨髓增生严重减低,2例并发严重肺部感染,1例并发面部急性蜂窝织炎,但无1例出现严重心、肝、肾并发症。初步结果表明,伊达比星是治疗难治性复发性急性白血病更有效的药物之一,但血像和骨髓像抑制明显,应加强支持保护治疗。
Eight patients with refractory recurrent acute leukemia were treated with idarubicin (Am-C), vincristine (VCR), prednisone and the like, with 5 cases of AML, ALL3 cases. Except one case of AML died of intracerebral hemorrhage, three of the seven cases were completely relieved (42.8%), two partially relieved (28.7%), two were ineffective and the total effective rate was 71.5% . 8 cases had obvious blood image suppression, 4 cases of severe myelodysplasia, 2 cases of severe pulmonary infection, 1 case of acute facial cellulitis, but none of the patients had serious heart, liver and kidney complications. Preliminary results show that, Ida Bixing is a more effective treatment of refractory recurrent acute leukemia drugs, but blood and bone marrow imaging significantly inhibited, should be strengthened to support the protection of treatment.