论文部分内容阅读
西班牙科学家近日于网上《美国实验生物学会联合会杂志》(FASEB J)在线公布了一项最新研究成果,他们发现,他汀类药物除了可通过阻断肝脏中胆固醇合成酶活性而发挥降血脂及降低心脏病和中风发生率的作用外,还能减缓端粒缩短速率,表明其可能具有抗衰老作用。端粒是染色体两端的DNA重复序列区域,对染色体起保护作用,可防止其融合和退化,它的严重缩短会限制细胞分裂,是细胞老化的标志,而端粒酶则可在每次细胞分裂后通过合成端粒来维持端粒长度。
Spanish scientists recently released a new online study online FASEB J. They found that statins can reduce blood fat and reduce blood lipids in addition to blocking cholesterol synthase activity in the liver Heart disease and the incidence of stroke, but also reduce the telomere shortening rate, indicating that it may have anti-aging effect. Telomere is a region of DNA repeats at both ends of a chromosome that protects the chromosome from fusions and degeneration, and severely shortened it to limit cell division, which is a hallmark of cellular aging, whereas telomerase can divide at each cell division The telomere length is maintained by the synthesis of telomeres.