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目的：探讨影响咽喉部增生性病变发病的相关因素。方法收集门诊因咽喉部病变行电子喉镜检查及治疗的471例患者的一般情况、临床病理资料及反流症状指数（RSI）、反流体征评分（RFS）并进行统计学分析。结果吸烟、饮酒、RSI、RFS 及胃病史与咽喉部是否出现增生性病变有相关性（P ＜0．05）；而年龄、性别、体质量指数（BMI）与咽喉部是否出现增生性病变无明显相关性。年龄、性别、吸烟、饮酒及 RFS 与咽喉部增生性病变的性质有显著相关性（P ＜0．001）；BMI 与咽喉部增生性病变性质有相关性（P ＜0．05）；RSI 及胃病史则与之无关。Logistic回归分析发现，年龄、性别、吸烟、饮酒及 RFS 评分是咽喉部增生性病变的独立危险因素（P ＜0．05）。结论影响咽喉部是否出现增生性病变的主要因素是吸烟、饮酒、RSI、RFS 及胃病史；增生物的良恶性则与年龄、性别、吸烟、饮酒、RFS 及 BMI 相关。“,”Objective To investigate the risk factors of proliferative laryngopharyngeal disease (PL D).Methods A total of 471 patients with PL Dwere included in this retrospective study.Their general information,clinical data,reflux symptom index (RSI)and reflux fluiding score (RFS)were statistically analyzed.Results Smoking,alcohol,RSI, RFS and gastrosis were correlated with PL D(P <0.05),while age,sex and BMI were not correlated.Age,sex, smoking,alcohol and RFS score were significantly correlated with the nature of PL D(P <0.001),BMI was signifi-cantly correlated (P <0.05),while RSI score and gastrosis were not correlated.Logistic regression analysis indicated that age,gender,smoking,alcohol and RFS score were independent risk factors for the development of PL D(P <0.05).Conclusions The risk factors for PL Dinclude smoking,alcohol,RSI,RFS and gastrosis.The benign or ma-lignant nature of PL Dis related to age,sex,smoking,alcohol,RFS and BMI.