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作者采用随机对照试验,将165名抗-HBs和抗-HBc阴性的医学生分成两组,83人于上臂三角肌或三头肌肌肉接种2μg血源性乙型肝炎疫苗(IM组);82名于上臂掌侧皮内接种同样的疫苗(ID组).两组均于0、1、2和6个月接种4次,于0、2、6和7个月采血.用放射免疫法检测抗-HBs和抗-HEc.对第7个月时抗-HBs滴度大于10IU/l但小于1000IU/l者在12个月时加强接种1剂2μg疫苗,并于13个月时采血;若第7个月时,接种者的抗-HBs滴度小于10IU/l,则再接种1剂20μg标准剂量疫苗.
The authors randomized 165 medical students with anti-HBs and anti-HBc to divide into two groups, and 83 of them inoculated with 2 μg of blood-borne hepatitis B vaccine (IM group) in the upper arm deltoid or tricep muscle. 82 The same vaccine was vaccinated intradermally (ID group) in the upper arm, and both groups were vaccinated 4 times at 0, 1, 2 and 6 months, and blood was collected at 0, 2, 6 and 7 months.A radioimmunoassay Anti-HBs and anti-Hec. One anti-HBs titer greater than 10 IU / l but less than 1000 IU / l at 7 months was boosted with 1 dose of 2 μg vaccine at 12 months and blood was collected at 13 months. At the seventh month, the vaccinated person has an anti-HBs titer of less than 10 IU / l, and one more dose of the 20 μg standard dose vaccine is then inoculated.