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采用溶剂搅拌法制备妥曲珠利羟丙基-β-环糊精包合物,考察了乙腈浓度、包合温度、主客分子比、pH值对回收率、包合率和含药率的影响,用显微镜法、薄层法及相溶解度法对包合物进行鉴定,测定包合物的饱和溶解度,并对包合机制进行了探讨.结果表明,优化工艺所制包合物平均回收率为86.45%,平均包合率为60.44%,平均含药率为7.00%,饱和溶解度达9.90mg/mL,具有良好的水溶性.
The solvent-agitation method was used to prepare the inclusion complex of tetamylamine and hydroxypropyl-β-cyclodextrin. The effects of acetonitrile concentration, inclusion temperature, host-guest molecular ratio and pH value on recovery, inclusion rate and drug inclusion rate , The inclusion complex was identified by microscopy, thin layer method and phase solubility method, the saturation solubility of the inclusion complex was determined, and the inclusion mechanism was discussed.The results showed that the average recovery rate of the inclusion complex was 86.45%, the average inclusion rate was 60.44%, the average drug content was 7.00% and the saturation solubility was 9.90mg / mL, which showed good water solubility.