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研究低分子量地黄多糖（ＬＲＰＳ）对ｐ５３基因表达的影响．方法：利用定量ＰＣＲ的方法检测ｐ５３基因表达的水平．结果：ＬＲＰＳ在最适抗肿瘤有效剂量２０和４０ｍｇ·ｋｇ－１条件下，Ｌｅｗｉｓ肺癌组织内ｐ５３基因的表达水平分别是１５２和１４８，对照组为０４６，环磷酰胺组为１６０．ＬＲＰＳ能使Ｌｅｗｉｓ肺癌组织内ｐ５３基因的表达明显增加．结论：ＬＲＰＳ对抗癌基因ｐ５３表达的影响是其抗肿瘤作用的机制之一．
To investigate the effect of low molecular weight Rhizoma Ligustici polysaccharide (LRPS) on p53 gene expression. Methods: The level of p53 gene expression was detected by quantitative PCR. Results: Under the optimal anti-tumor effective dose of LRPS, the expression levels of p53 gene in Lewis lung cancer tissues were respectively 1.52 and 1.48, the control group was 0.46, 1 60. LRPS can significantly increase the expression of p53 gene in Lewis lung carcinoma. Conclusion: The effect of LRPS on the expression of anti-oncogene p53 is one of the mechanisms of anti-tumor effect.