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目的探讨曲美他嗪联合阿托伐他汀治疗老年冠心病合并左侧心功能不全患者的疗效。方法选取80例老年冠心病合并左侧心功能不全患者,随机分为试验组和对照组,每组40例。两组基础治疗为利尿剂、洋地黄类、ACEI/ARB、β受体阻滞剂等,对照组加用阿托伐他汀10 mg/d,试验组在对照组治疗基础上加用曲美他嗪。对比试验组和对照组治疗前、治疗12个月的NYHA心功能分级及左室射血分数。结果试验组和对照组治疗前NYHA心功能分级(Ⅱ、Ⅲ、Ⅳ)及左心室射血分数分别为11例、19例、10例、(48.5±3.2)%及1例、20例、8例、(49.2±4.3)%,两组比较,差异无统计学意义(P>0.05);试验组和对照组治疗12个月的NYHA心功能分级(Ⅱ、Ⅲ、Ⅳ)及左心室射血分数分别为21例、18例、1例、(57.4±5.6)%及16例、19例、5例、(55.2±5.7)%,两组与治疗前比较,差异均有统计学意义(P<0.05)。结论曲美他嗪联合阿托伐他汀治疗老年冠心病合并左侧心功能不全患者,可有效改善其心功能,延缓疾病。
Objective To investigate the efficacy of trimetazidine combined with atorvastatin in the treatment of elderly patients with coronary heart disease and left heart failure. Methods Eighty elderly coronary heart disease patients with left ventricular dysfunction were selected and randomly divided into experimental group and control group, 40 cases in each group. The two groups of basic treatment for diuretics, digitalis, ACEI / ARB, β-blockers, etc., the control group plus atorvastatin 10 mg / d, the experimental group in the control group based on the treatment with trimetazidine Oxazine. The NYHA functional class and left ventricular ejection fraction were compared between the experimental group and the control group before treatment for 12 months. Results The cardiac function classification (Ⅱ, Ⅲ, Ⅳ) and left ventricular ejection fraction of NYHA before treatment in trial group and control group were 11, 19, 10 (48.5 ± 3.2)% and 1 (49.2 ± 4.3)%, there was no significant difference between the two groups (P> 0.05). The NYHA functional class (Ⅱ, Ⅲ, Ⅳ) and left ventricular ejection fraction The scores were 21, 18, 1, (57.4 ± 5.6)% and 16, 19 and 5 (55.2 ± 5.7)%, respectively, with significant differences between the two groups <0.05). Conclusion Trimetazidine combined with atorvastatin in elderly patients with coronary heart disease complicated with left ventricular dysfunction, can effectively improve their cardiac function and delay the disease.