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目的探讨遗传背景对AF的影响。方法房颤组121例、对照组100例,聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法鉴定AT1R基因1166位点基因型进行比较,Logistic回归分析基因型对房颤的独立危险性。结果房颤组AC+CC基因型频率、C等位基因频率均较对照组增高(P分别为0.017、0.013),与AA型比较,AC型+CC型者发生AF的风险率为3.657(95%CI:1.181～11.322),基因型、收缩压参与增加总体AF发生的概率(P分别为0.019、0.002),以AA型为参照,AC型+CC型发生AF的OR为4.132(95%CI:1.263～13.513)。结论携带AT1R基因1166位点C等位基因者有增加发生AF风险的倾向。
Objective To explore the effect of genetic background on AF. Methods The genotypes of AT1R gene at position 1166 were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 121 patients in the AF group and 100 in the control group. Logistic regression analysis was used to analyze the genotypes’ Independent danger. Results The frequency of AC + CC genotype and C allele in AF group were significantly higher than those in control group (P = 0.017, 0.013, respectively). Compared with AA genotype, the risk of AF in AC + CC genotype was 3.657 % CI: 1.181-11.322). Genotype and systolic blood pressure increased the probability of overall AF (P = 0.019 and 0.002 respectively). The OR of AC + CC genotype was 4.132 (95% CI : 1.263 ~ 13.513). CONCLUSIONS: Patients with the C allele at position 1166 of the AT1R gene have a tendency to increase the risk of developing AF.