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用一组抗MNC亚群的单克隆抗体及4种羊抗人Ig的F(ab′)_2对30例宫颈鳞癌及10例慢性宫颈夷组织中浸润的MNC各亚群的分布进行了研究。发现两类病变中浸润的细胞均以T细胞为主,各主要MNC亚群在两类病变中的分布并无统计学差异。然而HLA-DR~+T/T细胞比率在两者中有非常显著的差异(P<0.001),即慢性宫颈炎中浸润的T细胞大多是HLA-DR~+的活化T细胞,而宫项癌中者绝大多数均不表达HLA-DR抗原而处于非活化状态。这可能是局部细胞反应不能控制肿瘤生长的主要原因之一。
The distribution of MNC subpopulations in 30 cases of cervical squamous cell carcinoma and 10 cases of infiltrating cervical lymphoid tissue was studied using a panel of monoclonal antibodies against MNCs and 4 kinds of F (ab ’) _2 goat anti-human Ig . It was found that the infiltrating cells in both of the two types of lesions were mainly T cells. There was no significant difference in the distribution of the major MNC subtypes among the two types of lesions. However, the ratio of HLA-DR + T cells was significantly different between the two groups (P <0.001). Most of infiltrating T cells in chronic cervicitis were HLA-DR + activated T cells. The vast majority of cancers do not express HLA-DR antigen in a non-activated state. This may be one of the main reasons that local cellular responses do not control tumor growth.