论文部分内容阅读
目的:通过对突发性聋病人血中一氧化氮(NO)、丙二醛(M DA)、超氧化物歧化酶(SOD)含量的检测,探讨突聋与血氧自由基和自由基的清除剂SOD之间的关系。方法:采用硝酸还原酶法测定了30例突聋病人血中NO含量,并以25例同期体检正常的健康人为对照组;同时还用硫代巴比妥酸比色法测定M DA含量,用黄嘌呤氧化酶法测定SOD含量。结果:应用金纳多、能量合剂、克林奥(即马来酸桂哌齐特,钙通道阻滞药)联合静脉输入,突聋各组的听力均有不同程度提高,有效率在78.57%以上。治疗后同对照组相比,血清NO、M DA水平明显低于患病之初,而SOD活性明显高于治疗之前,P<0.01。结论:检测突聋病人血中NO、M DA、SOD的含量,能帮助我们探讨突聋的发病机理,估计预后。血氧自由基的升高可能是突聋发病因素之一,而SOD的含量可以帮助我们估计预后。
OBJECTIVE: To detect the levels of blood nitric oxide (NO), malondialdehyde (M DA) and superoxide dismutase (SOD) in sudden deafness patients and explore the relationship between sudden deafness and blood oxygen free radicals and free radicals Scavenger SOD relationship between. Methods: Nitric acid reductase method was used to determine the serum NO level in 30 cases of sudden deafness patients. 25 normal subjects were selected as normal control group. M DA content was measured by thiobarbituric acid colorimetry Determination of SOD by xanthine oxidase method. Results: With the combination of Ginaton, energy mixture, Clinotec (ie, Cinepazide maleate, calcium channel blocker) and venous input, the hearing ability of each group was improved to different extents, the effective rate was 78.57% the above. After treatment, compared with the control group, serum NO and M DA levels were significantly lower than the beginning of the disease, and SOD activity was significantly higher than before treatment, P <0.01. Conclusion: Detecting the content of NO, M DA and SOD in the blood of patients with sudden deafness can help us explore the pathogenesis of sudden deafness and estimate the prognosis. The increase of blood oxygen free radicals may be one of the pathogenesis of sudden deafness, and the content of SOD can help us to estimate the prognosis.