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目的探讨耐利奈唑胺粪肠球菌和屎肠球菌常用抗菌药物的耐药性,为临床治疗提供参考。方法收集2011年1月-2015年12月临床分离的非重复粪肠球菌和屎肠球菌,采用自动化药敏检测法进行药敏试验,其中替考拉宁采用纸片扩散法,结果判断参照CLSI的解释标准。结果共分离出耐利奈唑胺粪肠球菌46例,耐药率为3.6%;耐利奈唑胺屎肠球菌23例,耐药率为1.8%。临床分离的2种耐利奈唑胺粪肠球菌对替加环素、万古霉素及替考拉宁高度敏感。耐利奈唑胺屎肠球菌对奎奴普丁-达福普汀较为敏感,耐药率为13.0%;对青霉素和氨苄西林耐药率则达到100.0%。而耐利奈唑胺粪肠球菌对呋喃妥因、青霉素及氨苄西林有较高的敏感性,耐药率分别为4.3%、10.9%及13.0%;对奎奴普丁-达福普汀的耐药率则达到100.0%。结论 2种耐利奈唑胺肠球菌对抗菌药物耐药谱存在差异,提示应加强药敏试验,合理选用抗菌药物。
Objective To investigate the resistance of commonly used antimicrobials to Enteric-resistant Enterococci Enterococcus faecalis and Enterococcus faecium, and to provide a reference for clinical treatment. Methods The clinical isolates of Enterococcus faecalis and Enterococcus faecium isolated from January 2011 to December 2015 were collected. Susceptibility tests were performed using an automated drug susceptibility test. Teicoplanin was discarded by disk diffusion and the results were compared with the CLSI The interpretation of the standard. Results A total of 46 patients resistant to linezolid were found, with a resistance rate of 3.6%. 23 patients were resistant to linezolid of faecium. The resistance rate was 1.8%. Two clinical isolates of linezolid resistant Enterococcus faecium, vancomycin and teicoplanin highly sensitive. Resistant to nymphadenococci Enterococcus faecium was more sensitive to quinupristin than dalfopristin, with a resistance rate of 13.0% and a resistance rate of 100.0% to penicillin and ampicillin. The resistant-resistant linezolid to Enterococcus faecalis had a higher sensitivity to nitrofurantoin, penicillin and ampicillin, with resistance rates of 4.3%, 10.9% and 13.0%, respectively. The resistance rate to quinupristin-dalfopristin It reaches 100.0%. Conclusion Two kinds of resistant linezolid enterococci antibacterial drug resistance spectrum differences, suggesting that drug susceptibility testing should be strengthened, rational use of antimicrobial agents.