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目的:总结急诊重型颅脑损伤患者咪达唑仑诱导气管插管的效果。方法:回顾性分析2013年1月-2015年12月我院急诊救治的96例重型颅脑损伤患者的临床资料,按麻醉方案不同分为对照组(n=40)和研究组(n=56),对照组行地西泮麻醉,研究组行咪达唑仑麻醉,比较两组插管即刻生命体征及插管后连接呼吸机前血气分析情况。结果:研究组平均动脉压(MAP)、呼吸频率(RR)、心率(HR)、血氧分压(PaO_2)及二氧化碳分压(PaCO_2)均显著优于对照组(P<0.05)。结论 :急诊重型颅脑损伤患者使用咪达唑仑镇静行气管插管术较地西泮能更有效减轻气管插管时的心血管反应,而对呼吸功能几乎无影响。
Objective: To summarize the effect of midazolam induced tracheal intubation in patients with severe traumatic brain injury. Methods: The clinical data of 96 patients with severe craniocerebral injury who were treated in our hospital from January 2013 to December 2015 were retrospectively analyzed. According to the anesthesia plan, the patients were divided into control group (n = 40) and study group (n = 56) ). The control group received diazepam anesthesia. The study group was given midazolam anesthesia. The immediate signs of intubation and the blood gas analysis before intubation were compared between the two groups. Results: The MAP, RR, HR, PaO_2 and PaCO_2 of the study group were significantly better than those of the control group (P <0.05). CONCLUSIONS: Midazolam-administered tranquillotracheal intubation compared with diazepam in patients with emergent severe craniocerebral injury is more effective in reducing cardiovascular responses to intubation, with little effect on respiratory function.