论文部分内容阅读
目的探讨ＩＮＦ－α联合羟基脲（ＨＵ）治疗慢性粒细胞白血病的效果。方法对１２例Ｐｈ１阳性和ｂｃｒ／ａｂｌ基因阳性的ＣＭＬ患者进行治疗并定期观察治疗前后血象、骨髓象、染色体和ｂｃｒ／ａｂｌ基因的变化。结果全部病例均达血液学缓解，其中１例达细胞遗传学部分缓解，另１例患者不仅达细胞遗传学完全缓解，而且在治疗１６个月后ｂｃｒ／ａｂｌ基因消失。结论ＩＮＦ－α联合ＨＵ是治疗ＣＭＬ的有效方法，而且能达到分子生物学缓解的效果，早期治疗，ＩＮＦ－α剂量充足和持续的治疗是达到ＣＭＬ长期彻底缓解的重要因素。
Objective To investigate the effect of INF-α combined with hydroxyurea (HU) in the treatment of chronic myeloid leukemia. Methods Twelve patients with Ph1 positive and bcr/abl positive CML were treated and the changes of blood, bone marrow, chromosome and bcr/abl gene were observed before and after treatment. Results All cases achieved hematological remission, in which one case of cytogenetics was partially relieved, and the other patient not only achieved complete cytogenetic remission, but also disappeared after 16 months of treatment. Conclusion INF-α combined with HU is an effective method for the treatment of CML, and it can achieve the effect of molecular biology remission. Early treatment, adequate dose and sustained treatment of INF-α are important factors for long-term complete remission of CML.