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实验比较了K~+通道阻断剂氯化四乙基铵(TEA)及Ca~(2+)通道阻断剂维拉帕米(verapamil,Ver)对家兔缺血性心室肌不应期(ERP)的影响。结果表明,阻断冠脉10min及30min后,缺血中心区(CIZ)和缺血边缘区(BIZ)心肌ERP比缺血前均明显缩短,而TEA和Ver均能延长急性缺血性心肌的ERP,可能对心肌缺血引起的心律失常有预防作用。
The effects of K + channel blocker tetraethylammonium chloride (TEA) and Ca 2+ channel blocker verapamil (Ver) on ischemic ventricular muscle refractory period (ERP) impact. The results showed that the myocardial ischemic center (CIZ) and myocardial ischemic center (BIZ) were significantly shortened after occlusion of coronary artery 10min and 30min, while both TEA and Ver could prolong the acute ischemic myocardium ERP, may have a preventive effect on arrhythmia caused by myocardial ischemia.