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以ELISA法对77例常年性变应性鼻炎(PAR)与16例非变应性鼻炎(NAR)进行了血清粉尘螨特异性IgE检测,并与皮试、血清及鼻分泌物总IgE相对照,发现:该抗体的阳性率在二组分别为61.04％及31.20％,差异显著(P<0.05);PAR组中粉尘螨皮试与特异性IgE之间的符合率为67.69％,相关显著(P<0.025);PAR组无论血清或鼻分泌总IgE与血清粉尘螨特异性IgE均呈明显正相关(P<0.01及<0.05)。认为就多数病人来说,这一简而易行的体外变应原诊断法有可能代替皮试,列为PAR的常规诊断。
Serum dust mite-specific IgE was detected by ELISA in 77 cases of perennial allergic rhinitis (PAR) and 16 cases of non-allergic rhinitis (NAR), and compared with skin test, serum and total IgE of nasal secretions The results showed that the positive rate of this antibody in the two groups was 61.04% and 31.20%, respectively, with significant difference (P <0.05). The coincidence rate of dust mite skin test with specific IgE in PAR group was 67.69% P <0.025). There was a significant positive correlation between total IgE of serum or nasal secretion and specific IgE of serum dust mite in PAR group (P <0.01 and <0.05). For most patients, this simple and convenient in vitro allergen diagnosis is likely to replace skin tests as a routine diagnostic for PAR.