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采用酶细胞化学、粘液组织化学和雌激素受体（ＥＲ）亲和组织化学方法，对３７例胃粘液腺癌和印戒细胞癌的功能分化状态进行了检测，对二者的生物学特征作了对比分析。结果：胃粘液腺癌为一类向单一粘液分泌功能分化，以局部浸润生长为主的胃癌细胞类型；印戒细胞癌为一种功能分化紊乱且兼具吸收功能与粘液分泌功能、浸润扩散依赖于雌激素的特殊的胃癌细胞类型；印戒细胞癌伴粘液湖形成者（混合型），其生物学特征更接近于印戒细胞癌。提示：临床判断不同功能分化之胃粘液癌的预后和推测其转移扩散途径时，对各自不同的生物学特征应给予足够的重视。
The functional differentiation status of 37 cases of gastric mucinous adenocarcinoma and signet-ring cell carcinoma was examined by enzyme cytochemistry, mucohistochemistry, and estrogen receptor (ER) affinity histochemistry. A comparative analysis. RESULTS: Gastric mucinous adenocarcinoma was a kind of gastric cancer cell type that differentiated to a single mucus secretory function and was mainly infiltrated and grew. Signet ring cell carcinoma was a disorder of functional differentiation and had both absorption function and mucus secretion function, and invasion and spread depended on it. Specific gastric cancer cell types for estrogen; signet ring cell carcinoma with mucus lake formers (hybrid), whose biological characteristics are closer to signet-ring cell carcinoma. Tip: When judging the prognosis of gastric mucinous carcinoma with different functional differentiation and predicting its metastatic diffusion pathway, we should pay enough attention to its different biological characteristics.