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目的探讨重型病毒性肝炎预后影响因素。方法回顾2005年1月—2010年1月商丘市第三人民医院诊治的重型病毒性肝炎382例临床资料进行总结分析。结果本组重型病毒性肝炎382例,经积极治疗死亡236例,病死率61.78%;存活146例,生存率38.22%;<20岁组与21~50岁组病死率比较P>0.05无显著差异性。<20岁组和21~50岁组与>50岁组病死率比较比较P<0.05有显著差异性。各临床分型病死率比较P<0.05有显著差异性。两组生化指标检测比较P<0.05有显著差异性。结论重型病毒性肝炎患者年龄较轻病死率较低;临床分型病死率呈现为急性重型肝炎病死率>慢性重型肝炎病死率>亚急性重型肝炎病死率。临床生化指标总胆红素、胆固醇、凝血酶原活动度、白蛋白、甲胎蛋白等对于判断重型肝炎预后有一定意义。
Objective To investigate the prognostic factors of severe viral hepatitis. Methods The clinical data of 382 cases of severe viral hepatitis diagnosed and treated by the Third People ’s Hospital of Shangqiu City from January 2005 to January 2010 were retrospectively analyzed. Results 382 cases of this group of severe viral hepatitis, 236 patients died of active treatment, the mortality rate was 61.78%; 146 cases of survival, the survival rate was 38.22%; <20 years of age group and 21 to 50 years old group mortality P> 0.05 no significant difference Sex. <20 years old group and 21 to 50 years old group and> 50 years old group mortality comparison P <0.05 significant difference. The clinical classification of mortality compared P <0.05 significant difference. Two groups of biochemical index detection P <0.05 significant difference. Conclusions The younger age of patients with severe viral hepatitis is lower. The morbidity of clinical type presents with the mortality of acute severe hepatitis, the mortality of chronic severe hepatitis and the mortality of sub-acute severe hepatitis. Clinical biochemical indicators of total bilirubin, cholesterol, prothrombin activity, albumin, alpha-fetoprotein, etc. for the judgment of prognosis of severe hepatitis has some significance.