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临床实践中广泛应用雌激素制剂于激素避孕及绝经期前后的取代治疗。许多观察提示,全身性雌激素治疗也会干扰免疫机制。有报道,雌激素能降低结核菌素的皮肤敏感性并延缓异体移植的排斥反应。给妇女服用口服避孕药和用雌激素取代治疗过程中,也曾观察到淋巴细胞反应性的变化。雌激素通过与靶细胞内的特异性受体结合而起作用。大多数报道指出雌激素可以改变细胞介导的免疫反应,但循环中的淋巴细胞并不具有雌激素受体。细胞免疫机能是胸腺依赖性的。本文观察了17β-雌二醇与
In clinical practice, estrogen preparations are widely used in hormone contraception and replacement therapy before and after menopause. Many observations suggest that systemic estrogen therapy can interfere with the immune system. It has been reported that estrogen can reduce the skin sensitivity of tuberculin and delay allograft rejection. Changes in lymphocyte reactivity have also been observed during oral contraceptives and estrogen replacement therapy in women. Estrogens work by binding to specific receptors within target cells. Most reports point out that estrogen can change the cell-mediated immune response, but circulating lymphocytes do not have estrogen receptors. Cellular immune function is thymus-dependent. In this paper, 17β-estradiol was observed