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正常青春期发动源于下丘脑促性腺激素释放激素(LHRH)脉冲式分泌的增加。近年来的研究表明,多种兴奋性和抑制性神经调节因子共同参与了此过程。本文对3种抑制性神经调节因子γ-氨基丁酸、神经肽Y及褪黑激素与青春期发动的关系进行了综述,其中γ-氨基丁酸通过对LHRH神经元直接和间接的控制作用,在雌性灵长目动物青春期发动中发挥了重要的抑制作用。另外,褪黑激素、神经肽Y也参与影响了青春期发动过程中下丘脑LHRH神经元的功能活动。
Normal adolescent motility results from increased pulsatile secretion of hypothalamic gonadotrophin-releasing hormone (LHRH). Recent studies have shown that a variety of excitatory and inhibitory neuromodulators are involved in this process. This review summarizes the relationship between the three inhibitory neurotransmitters γ-aminobutyric acid, neuropeptide Y and melatonin and adolescent onset, in which γ-aminobutyric acid, through direct and indirect control of LHRH neurons, Female primates play an important inhibitory role in adolescent onset. In addition, melatonin and neuropeptide Y are also involved in the functional activity of hypothalamic LHRH neurons during puberty.