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Influenza is an acute respiratory communicable disease which, during epidemics, can cause high morbidity and mortality. Since 1949, WHO established an international network for the surveillance of influenza mainly based on sentinel physicians report of clinical cases of ILI (influenza-like illness) to a central registry. Traditional Chinese Medicine (TCM) considered this condition as an externally contracted disease caused by pathogenic factors and have developed from thousands years ago a rich system for its prevention and treatment expressed in the "Shang Han Lun". The purpose of this study was to assess the effects of Chinese medicinal patent formulas according to TCM principles of "Shang Han Lun" in treating Portuguese people with established diagnosis of ILI condition by comparing it with western current treatment regimens. Sixty patients from the Clinic of TCM College of Lisbon and from the clinical sets of Portuguese Association of Acupuncture and TCM in Lisbon region that have ILI condition were randomized allocated to Experimental (9 males of 48,00±21,66 years of age and 21 females of 42,19±16,76 years of age) and Control Group (8 males of 53,63±18,49 years of age and 22 females of 50,05±18,14 years of age). A diagnostic tool and professional follow-up sheets for externally diseases caused by Cold have been developed, validated and applied in the first session of treatment (24h maximum after the onset of symptoms) and after three and ten days. The follow-up registration sheet of the patient was answered every day during 10 days after the treatment. T-Student, Mann-Whitney U test and Chi squared tests were used to compare the quantitative and nominal variables, respectively, of the two independent samples. All the statistical analyses were done using SPSS. 13.0. The significant level was settle to 5％ (p=0,05). Since the two groups were not significantly different in the beginning of treatment in relation to the symptoms that define ILI condition it was possible to verify that after the first three days the recovery rate was significantly different in experimental versus control group (p<0,000) with RR 2,95±2,61 to 8,57±3,59 respectively and that there was a marked improvement of clinical symptoms and signs in the experimental group versus a general improvement in the control one. In the experimental group it was also observed seven different types of syndromes related with ILI condition treated with seven different manufactured formulas. In this research it has been possible to verify that manufactured classic prescriptions of Shang Han Lun can treat ILI conditions if used with the clinic decision though method that is implicit in this Classic monograph.