Hepatoprotective Effect of Several Traditional Medicinal Herbs on Hepatic Injury in Mice or Rats

• 作 者: 金学军
• 机 构: 延边大学
• 出 处: 延边大学
• 发表日期: 2004年期
• 关键词: 植物药 肝损伤 保护作用 中药药理学

OBJECTIVE: To study the protective effect of the extract of Salvia miltiorrhiza , scutellaria baicalensis and Sedum sarmentosum on liver injury in mice or rats.
METHODS: Three liver injury models induced by CCL4,D-galactosamine(D-GalN) and D-galactosamine(D-GalN) /Lipopolysaccharid(LPS)in mice or rats. pretreatment with extract of Salvia miltiorrhiza, scutellaria baicalensis in mice or rats, the levels of serum enzyme ALT、 AST were determined.Pretreatment mice with the Sedum sarmentosum (CPC), and the effects of survival on acute liver injury were observed. The levels of serum enzyme ALT、 AST and TNF-α,the NF-KB activities and DNA damage in mice liver were observed or determined.
RESULTS: Pretreatment mice with 55％ ethanol extract of Salvia miltiorrhiza(200and 500mg/kg, intraperittoneal) significantly reduced levels of serum enzyme ALT,AST in mice with D-GalN and D-GalN/LPS-induced liver injury. Pretreatment rats with 55％ ethanol extract of Salvia miltiorrhiza(0.5 and 1.5g/kg ,p.o) significantly reduced levels of serum enzyme ALT, AST in rats with CCL4-induced liver injury.Pretreatment mice with extract of scutellaria baicalensis (200 and 500mg/kg,,intraperittoneal) significantly reduced levels of serum enzyme ALT, AST in mice with D-GalN and D-GalN/LPS-induced liver injury. Pretreatment mice with sedum sarmentosum (50 or 100mg/Kg, intraperittoneal) significantly increased the survival on mice acute liver injury, and then significantly reduced the levels of serum enzyme ALT、 AST and TNF-α Activities. On the other hand, sedum sarmentosum significantly suppressed NF-KB activities and DNA damage on mice acute liver injury.
CONCLUSION: Extract of Salvia miltiorrhiza, scutellaria baicalensis and Sedum sarmentosum has protecting effects for mice or rats in liver injury.