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  5. BDNF Mediated TrkB Activation Contributes to The EMT Progression in Human Salivary Adenoid Cystic Ca

BDNF Mediated TrkB Activation Contributes to The EMT Progression in Human Salivary Adenoid Cystic Ca

来源 :2014xi`an Conference of International Society for Maxillofac | 被引量 : 0次 | 上传用户：ruinx
【摘 要】
：
Purpose: Brain-derived neurotrophic factor(BDNF)and its receptor Tropomysin-related kinase B(TrkB)are over-expressed in a series of malignancies and associated with the tumor progression.Recent studie
【作 者】
：
Jia Sen Wang Weixi Hu Zhiqiang Shan Chun Wang Lei Wu Baolei Yang Zihui Lei Delin Yang Xinjie 
【机 构】
：
State Key Laboratory of Military Stomatology,Department of Oral and Maxillofacial Surgery,School of
【出 处】
：
2014xi`an Conference of International Society for Maxillofac
【发表日期】
：
2014年4期
【关键词】
：
Salivary adenoid cystic carcinoma EMT BDNF TrkB 
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　　Purpose: Brain-derived neurotrophic factor(BDNF)and its receptor Tropomysin-related kinase B(TrkB)are over-expressed in a series of malignancies and associated with the tumor progression.Recent studies indicated that BDNF/TrkB axis may participate in the epithelial-mesenchymal transition(EMT)of malignant epithelial tumours.However,the roles of BDNF/TrkB in salivary adenoid cystic carcinoma(SACC)have been poorly investigated.The present study was aimed to investigate whether BDNF and TrkB expression is correlated with the clinical progression of SACC and whether BDNF/TrkB axis is associated with the EMT induction in SACC cells.
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