【摘 要】
：
Abdominal aortic aneurysm (AAA) is a severe degenerative disease characterized by degradation of extracellular matrix (ECM) with increased matrix metalloproteinases (MMPs) and inflammatory reaction.Do
【机 构】
：
Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University.Bei
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
论文部分内容阅读
Abdominal aortic aneurysm (AAA) is a severe degenerative disease characterized by degradation of extracellular matrix (ECM) with increased matrix metalloproteinases (MMPs) and inflammatory reaction.Doxycycline (DOX) has been reported to exert therapeutic effects against AAA in animal experiments as well as human trials.
其他文献
Zhejiang Huahai is the first and leading Chinese pharmaceutical company to export finished dosage forms to highly regulated markets, such as US and Europe.The company has marketed about 20 oral drug p
The allover level of the excipient standards adopted in Chinese Pharmacopoeia 2015 volume Ⅳ edition is improving significantly, including the improving the excipient standards system, increasing the e
Pharmaceutical formation consists of bioactive main drug and excipients with specific functions.The property of tablet is determined by the chemical structure and characteristics of excipients.As the
With the implementation ofICH Q8, Q9, Q10 and Q11 guidelines and the USFDA Process Validation guidance and issue of EMAs Process Validation guideline and Annex 15, the need to understand the science-a
The native pharmaceutical industry is currently undergoing a cosmic change because of the reform of the drug registration system which will make an important milestone for CFDA to reform itself to be
Gelatine based two-piece hard capsules are commonly used as a storage medium for dry,powdered pharmaceutical formulations.However, the well-recognized gelatine drawbacks, such as animal sources, high
Co-delivery of chemotherapeutic drug and microRNA is a promoting strategy for tumor therapy due to its synergistic effect.In our study, hydrophobic doxorubicin (DOX) and negative miR-34a were simultan
Amorphous solids are generally more soluble and faster dissolving than their crystalline counterparts, which makes them useful for delivering poorly soluble drugs whose bioavailability is limited by t
Nanotechnology has received extraordinary attention recently due to its burgeoning role in pharmaceutical research.The materials composing the nanoparticles produce fascinating and diverse functionali
Manufacturability is one of the important properties of later stage and launched pharmaceutical products.Suitable process and robust process parameter control are the keys for a well controlled produc