Peroxisome proliferator-activated receptor delta mediates the vascular benefits of metformin through

• 作 者: WaiSanCheang[1]XiaoYuTian[1]WingTakWong[2]YuHuang[1]
• 机 构: Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, The Chinese University
• 出 处: 第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会
• 发表日期: 2013年期

　　Background-5 adenosine monophosphate-activated protein kinase (AMPK) has been shown to interact with peroxisome proliferator-activated receptor delta (PPARδ) to induce gene expression synergistically and activation of AMPK inhibits endoplasmic reticulum (ER) stress.We aim to investigate whether PPARδ is an important mediator for the vascular benefits of anti-diabetic drug metformin (AMPK activator) in ameliorating ER stress and endothelial dysfunction in high-fat diet-induced obese (DIO) mice.