【摘 要】
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Several psychiatric disorders are associated with aberrant white matter development,suggesting oligodendrocyte and myelin dysfunction in these diseases.Radi
【机 构】
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DepartmentofHistologyandEmbryology,ThirdMilitaryMedicalUniversity,Chongqing400038,PRChina2SouthwestE
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Several psychiatric disorders are associated with aberrant white matter development,suggesting oligodendrocyte and myelin dysfunction in these diseases.Radial glia cells (RGCs) have been implicated in generation of oligodendrocyte precursor cells (OPCs),although the underlying mechanism remains unclear.Our previous studies have indicated that liver x receptor β (LXRβ) is involved in the development of RGCs.Here, we demonstrate that loss of LXRβ function leads to abnormality in locomotor activity and exploratory behavior, signs of anxiety, and hypomyelination in the corpus callosum and optic nerve, providing in vivo evidence that LXRβ deletion delays both oligodendrocyte differentiation and maturation.Remarkably, along the germinal VZ-SVZ and corpus callosum there is reduced OPC production from RGCs in LXRβ-/-mice.Conversely, in cultured RGC an LXR agonist led to increased differentiation into OPCs.Collectively, these results suggest that LXRβ, by driving RGCs to become OPCs in the dorsal cortex, is critical for white matter development and CNS myelination, and point to the involvement of a novel nuclear receptor in psychiatric disorders.
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