【摘 要】
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Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial.This study was aimed to determin
【机 构】
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Postgraduate Team, Chinese PLA General Hospital, Beijing 100853, China;Department of Radiation Oncol
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Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial.This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis, We searched the electronic databases of PubMed, Embase, Web of Science,and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016.Pooled hazard ratios (HRs) and 95% confidence intervals (Cis) were used to estimate the impact of B7-H3 on overall survival (OS).Combined odds ratios (Ors) and 95%Cis were utilized to evaluate the correlations between B7-H3 and clinicalpathological features.This meta-analysis finally included 7 studies with 864 patients.The results showed that B7-H3 had no significant association with OS (HR=0.88, 95%CI: 0.36-2.13, p=0.776).High B7-H3 expression was a significant indicator of lymph node metastasis (OR=3.92, 95% CI: 2.65-5.81, p<0.001), and advanced TNM stage (OR=3.53, 95%CI: 2.45-5.09, p<0.001).B7-H3 has the potential to serve as a marker of tumor aggressiveness and lymph node metastasis in NSCLC.However, due to several limitations, further large-scale studies are needed to validate our results.
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