Modulating balance of synaptic and extrasynaptic NMDA receptors(NMDARs)shows priority over nonselect

• 作 者: HUANG Yan SHEN Wei LIU Gang ZHOU Wen-xia ZHANG Yong-xiang
• 机 构: Beijing Institute of Pharmacology and Toxicology;State Key Laboratory of Toxicology and Medical Coun
• 出 处: 第十七届全国神经精神药理学学术会议
• 发表日期: 2016年5期
• 关键词: beta-amyloid NR2A NR2B balance Alzheimer disease

　　OBJECTIVE Alzheimer disease(AD)patients suffer a disturbance in the balance between synaptic NMDARs(NR2A,mediating the protective pathway)and extrasynaptic NMDARs(NR2B,mediating the excitotoxic pathway),and this study aim to find out whether restoring the balance of NR2A and NR2B is beneficial for AD.METHODS Aβ treated hippocampal slices and Aβ icv injection animals were used as AD models in this study.