Transplantation of miR-219-overexpressed oligodendrocyte precursor cells improves myelination and pr

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户:dtj77
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  We focus on the potential of miR-219 for stimulating oligodendrocytes lineage cells production from mouse embryonic stem cells(mESCs)and myelination after transplanting miR-219-overexpressed OPCs to cuprizone-induced demyelination rodent model.
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GDNF(glial cell-line derived neurotrophic factor,)是一种分泌性蛋白,可促进胶质瘤细胞增殖 。 GDNF 对胶质瘤细胞的增殖作用须通过跨膜信息传递,即受体的介导才能实现 。
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Inosine has been shown playing an important role in the injury and repair of the central nervous system(CNS).Our previous experiments also showed that inosine can protect cultured rat oligodendrocytes