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In this study,an orally-administered macrophage-targeting peptide delivery system was constructed through in situ self-assembly of Q 11 peptide inside hollow glucan particles (GPs).The glucan shell efficiently protected the encapsulated peptide from enzymatic degradation in the gastrointestinal tract.β-1,3-(D) glucan is recognized by the membrane receptor Dectin-1,which is highly expressed by intestinal antigen-presenting cells including macrophages.GPs are thus efficiently phagocytized by intestinal macrophages.This study is applicable for the development of orally-delivered macrophage-targeting systems for effective immunotherapies.