Amino acid residue E543 in JAK2 C618R is a potential therapeutic target for myeloproliferative disor

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：wilsai

【摘要】

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【作者】

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Qingyun Wu Huayan Guo Lingyu Zeng Kailin Xu

【机构】

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Department of Hematology,the Affiliated Hospital of Xuzhou Medical College

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Janus kinase 2 (JAK2) is an important mediator of cytokine receptor signaling and plays a key role in the hematopoietic and immune responses.The acquired JAK2 C618R somatic mutation is detected in a subset of myeloproliferative disorders (MPDs) patients and presumed to be a biomarker for MPDs.

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Amino acid residue E543 in JAK2 C618R is a potential therapeutic target for myeloproliferative disor

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