Small GTP-binding proteins, also known as small GTPases, regulate diverse processes in eukaryotic cells such as signal transduction, cell proliferation, cytoskeletal organization, and intracellular me
Interferon regulatory factor 3 (IRF3) plays an essential role in virus-induced type Ⅰ interferon (IFN) production and host antiviral immune responses.However, excessive immune responses will do harm t
Lysophosphatidic acid (LPA) is an important phospholipid mediator in inflammation and immunity.However, the mechanism of LPA regulation during inflammatory response is largely unknown.Autotaxin (ATX)
Being a first-line defense, the epidermis is in constant confrontation against pathological or mechanical insults that disrupt the epidermal architecture.
Osteopontin (OPN) is a multifunctional protein involved in both innate immunity and adaptive immunity.However, the function of OPN, especially the intracellular form OPN (iOPN) on antiviral immune res
Jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLRs) as antigen receptors to mount adaptive immune responses.Lampreys have two populations of lymphocytes ex