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The cytosolic recycling process of autophagy plays an important role in many age-related diseases and has been directly linked to aging, including in the nematode C.elegans.As a critical process to ensure cellular homeostasis especially in stressful conditions, autophagy has been found regulated at both post-translational and transcriptional levels.One particular example of the latter is the helix-loop-helix transcription factor TFEB, a key transcriptional regulator of autophagy-related genes, which we have found plays a critical and possibly conserved role in longevity determination.In addition to transcriptional regulation of autophagy,our lab has recently discovered a novel post-translational mode of autophagy regulation involving direct phosphorylation of the central autophagy protein LC3 and with potential relevance to immunity.I will here discuss our progress on understanding the different mechanisms employed by cells and organisms to regulate autophagy in response to stressors such as aging and disease.