Inhibiting ROS Decreased Ischemic Brain Injury through Reducing Accumulated Zinc

• 作 者: Feng Yan Zhao Yongmei
• 机 构: Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing,
• 出 处: 首都医科大学第四届研究生学术论坛第二分论坛
• 发表日期: 2016年8期
• 关键词: ROS zinc ischemia

　　Back ground and purpose: Both oxidative stress and the overload of zinc ions (Zn2+) had been implicated in ischemic brain injury.However,whether there was a mutually influence between reactive oxygen species (ROS) and zinc ions following transient focal cerebral ischemia remain to be fully elucidated.Here,we investigated whether scavenging ROS and inhibiting the generated ROS could decrease the intracellular levels of zinc and finally reduce brain damage and improve neurological outcomes after transient focal cerebral ischemia.