Adenosine A2A receptor is involved in the somnogenic effect of Prostaglandin D2

• 作 者: Wei-MinQU[1]Zhi-LiHUANG[2]YoshihiroURADE[1]
• 机 构: Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Prostaglandin (PG) D2 is one of the most potent sleep-promoting substances.PGD2-induced sleep was inhibited by an antagonist of adenosine A2A receptors (A2AR),suggesting that adenosine A2AR mediates the sleep-promoting effect of PGD2.In the present study,we used A2AR knockout (KO) mice to further explore the involvement of adenosine receptor subtypes in the somnogenic effect of PGD2.An A2AR agonist,CGS21680,at doses of 0.04,0.2,1 and 5 pmol/min increased non-rapid eye movement (NREM) sleep in wild-type (WT) mice after infusion into the lateral ventricle in a dose-dependent manner,but not at all in A2AR KO mice,as compared with the baseline day.In contrast,an agonist of adenosine A1 receptors (A1R),cyclopentyladenosine,did not affect sleep profiles in WT mice at a dose of 1 pmol/min and increased NREM sleep slightly at a dose of 5 pmol/min.