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  5. APM1 gene variants-11377C/G and 4545G/C are associated respectively with obesity and with non-obesit

APM1 gene variants-11377C/G and 4545G/C are associated respectively with obesity and with non-obesit

来源 :第八次全国医学遗传学学术会议(中华医学会2009年医学遗传学年会) | 被引量 : 0次 | 上传用户：zjlyqgf888
【摘 要】
：
In order to explore the different genetic background of non-obese and obese type 2 diabetes, we tried to genotype six SNPs (-11391G/A,-11377C/G,-10068G/A, G54V,Y111H and 4545G/C) inthe adipose most ab
【作 者】
：
王西珍 张思仲 陈元仲 刘合煜 兰彩莲 陈雪香 池述广 陈素云 张炜 
【出 处】
：
第八次全国医学遗传学学术会议(中华医学会2009年医学遗传学年会)
【发表日期】
：
2009年4期
【关键词】
：
Adiponectin Type 2 Diabetes Obesity Diabesity Single Nucleotide Polymorphisms 
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　　In order to explore the different genetic background of non-obese and obese type 2 diabetes, we tried to genotype six SNPs (-11391G/A,-11377C/G,-10068G/A, G54V,Y111H and 4545G/C) inthe adipose most abundant gene transcript-1 (APM1) gene in 338 type 2 diabetes (T2D) patients and 460 non-diabetic subjects by PCR-RFLP.Among these mutations, the 4545G/C mutation (rs1063539) contributed to the genetic risk of T2D in the non-obese group (OR =2.34, 95 % CI: 1.31-4.21, P =0.004), and 57% of the risk is related to this polymorphism.
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