Improvement of dissolution rate and bioavailability of puerarin flavones by dropping pills based on

• 作 者: HongboFan;YuWang;GuangyuanZhang;ShilinSun;QingxiangGuan;
• 机 构: Department of Pharmacy,School of Pharmacy,Jilin University,Changchun 130021,China
• 出 处: 2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2014年期

　　Solid dispersion technology has been widely applied to improve the solubility and dissolution rate of poorly water-soluble drugs, owing to the formation of high-energy metastable forms of the drug in the polymer such as amorphous form Moreover, amorphous fraction, particle size reduction and particle wettability of solid dispersion can contribute to an observed improvement of bioavailability of such hydrophobic compounds [1].