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目的:观察钙敏感受体(CaSR)在大鼠低氧性肺动脉高压形成过程中的表达规律及其对肺小动脉中膜表型转化的影响。方法:30只雄性Wistar大鼠随机分为对照组、低氧7 d组、低氧14 d组、低氧21 d组、低氧21 d+新霉素(CaSR激动剂)组和低
OBJECTIVE: To observe the expression of calcium sensitive receptor (CaSR) during hypoxia-induced pulmonary hypertension in rats and its effect on mesangial phenotype of pulmonary arterioles. Methods: Thirty male Wistar rats were randomly divided into control group, hypoxia for 7 d, hypoxia for 14 d, hypoxia for 21 d, hypoxia for 21 d and neomycin (CaSR agonist)